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51.
Yukimasa Aida Juntaro Nogami Dr. Haruki Sugiyama Prof. Dr. Hidehiro Uekusa Prof. Dr. Ken Tanaka 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(55):12579-12588
The enantioselective synthesis of polycyclic aromatic hydrocarbon (PAH)-based planar chiral cyclophanes was achieved for the first time by the rhodium-catalyzed intramolecular regio- and enantioselective [2+2+2] cycloaddition of tethered diyne-benzofulvenes followed by stepwise oxidative transformations. The thus synthesized planar chiral bent cyclophanes, that possess bent p-terphenyl- and 9-fluorenone-cores, were converted to 9-fluorenol-based ones with excellent ee values of >99 % by diastereoselective 1,2-reduction. These 9-fluorenol-based cyclophanes exhibited high fluorescence quantum yields, which were significantly higher than that of an acyclic reference molecule (78–82 % vs. 48 %). The bending effect on the chiroptical property was also examined, which revealed that the anisotropy factors (gabs values) for electronic circular dichroism (ECD) of these 9-fluorenol-based planar chiral bent cyclophanes increase as the tether length becomes shorter. 相似文献
52.
Yeray Dorca Roberto Sánchez-Naya Jesús Cerdá Dr. Joaquín Calbo Dr. Juan Aragó Dr. Rafael Gómez Prof. Dr. Enrique Ortí Prof. Dr. Luis Sánchez 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(64):14700-14707
A comparative investigation of the chiral amplification features of a series of three families of C3-symmetric tricarboxamides, 1,3,5-triphenylbenzenetricarboxamides (TPBAs), benzenetricarboxamides (BTAs) and oligo(phenylene ethynylene) tricarboxamides (OPE-TAs), is here reported. As previously observed for BTAs and OPE-TAs, a similar dichroic response is obtained for TPBAs decorated with one, two or three chiral side chains bearing stereogenic centers, thus confirming the efficient transfer of point chirality to the supramolecular helical aggregates. Unlike BTAs and OPE-TAs, the chiral amplification ability of TPBAs in majority rules experiments shows a negligible dependence on the number of chiral centers per monomeric unit, and stands the largest among the series of tricarboxamides. Detailed experimental and theoretical studies demonstrate that the rotation angle between the TPBA units in the helical stack is intermediate to that observed for BTAs and OPE-TAs. This feature strongly conditions the steric interactions between vicinal molecules in the stack and the final chiral amplification outcome. Furthermore, theoretical calculations show that achiral side chains favor the interdigitation of the helical aggregates and thereby the formation of bundle superstructures. 相似文献
53.
本文提出了对于手性药物普萘洛尔手性识别和手性分析的新方法。 该方法引用基于氧化石墨烯的指数富集配体系统进化筛选技术(GO-SELEX),经过10轮优化筛选出对心血管药物普萘洛尔有高度亲和力的特效适配体。 然后通过共振瑞利散射光谱法(RRS)对反应体系进行特效性检测,实验表明S-普萘洛尔和R-普萘洛尔有迥然不同的光谱差异,S-普萘洛尔与特效适配体结合后的RRS显著增强,而R-普萘洛尔与适配体结合后的RRS几乎没有变化。 据此可以对心血管药物手性普萘洛尔进行有效的手性识别。 在考察反应体系和实验条件的基础上,可对S-普萘洛尔进行实验检测,同时对外消旋体中的R-普萘洛尔进行计算分析。 实验对S-普萘洛尔的线性范围为5~275 nmol/L,检测限为0.5 nmol/L。 方法应用于外消旋药片的分析检测,结果令人满意。 实验表明,RRS检测特效适配体结合的手性靶标体系会彰显不同的光谱差异,从而可对手性对映体进行手性识别,尤其是可利用其光谱差异实现同时测定的手性分析,方法可在特殊情形下不经分离而同时测定手性对映体,具有推广应用价值。 相似文献
54.
Duloxetine (DLX) is a widely used antidepressant drug belonging to the class of selective serotonin and norepinephrine reuptake inhibitors (SNRIs); its efficacy has been demonstrated in the treatment of not only major depressive disorders but also diabetic neuropathic pain, generalized anxiety disorder, fibromyalgia or stress urinary incontinence. It is a chiral substance and is used in therapy in the form of the enantiopure S‐DLX, which is twice as active as R‐DLX. Several methods have been published for the achiral and chiral determination of DLX in pharmaceuticals, biological materials and environmental samples, the majority using liquid chromatography and capillary electrophoresis coupled with different detection techniques (UV detection, fluorescence, mass spectrometry). The aim of the current review is to provide a systematic survey of the analytical techniques used for the determination of DLX from different matrices. 相似文献
55.
构造一个具有复合幂函数的三维连续自治混沌系统。系统的状态方程仅有5项,其中一项是指数小于1的复合幂函数。该系统具有结构简单、非双曲平衡点、吸引子共存的性质,展现出了复杂的动力学行为。首先,对系统的动力学行为进行分析,包括李雅普诺夫(Lyapunov)指数谱、分岔图以及庞加莱映射等,结果表明此系统具有混沌特性。然后进行混沌系统的电路设计,电路仿真结果验证了理论分析的正确性。 相似文献
56.
Nafissa Dehimeche Bruno Buatois Nadia Bertin Michael Staudt 《Molecules (Basel, Switzerland)》2021,26(1)
The in-vivo monitoring of volatile organic compound (VOC) emissions is a potential non-invasive tool in plant protection, especially in greenhouse cultivation. We studied VOC production from above and belowground organs of the eight parents of the Multi-Parent Advanced Generation Intercross population (MAGIC) tomato population, which exhibits a high genetic variability, in order to obtain more insight into the variability of constitutive VOC emissions from tomato plants under stress-free conditions. Foliage emissions were composed of terpenes, the majority of which were also stored in the leaves. Foliage emissions were very low, partly light-dependent, and differed significantly among genotypes, both in quantity and quality. Soil with roots emitted VOCs at similar, though more variable, rates than foliage. Soil emissions were characterized by terpenes, oxygenated alkanes, and alkenes and phenolic compounds, only a few of which were found in root extracts at low concentrations. Correlation analyses revealed that several VOCs emitted from foliage or soil are jointly regulated and that above and belowground sources are partially interconnected. With respect to VOC monitoring in tomato crops, our results underline that genetic variability, light-dependent de-novo synthesis, and belowground sources are factors to be considered for successful use in crop monitoring. 相似文献
57.
多齿配体2-咪唑乙酸(Hima)、4,4'-连吡啶分别与金属盐Pb(NO3)2和AgNO3反应,得到[Pb2(4,4'-bipy)(ima)(NO3)3]n(1, 3D framework)和[Ag4(4, 4'-bipy)3(ima)2(NO3)2(H2O)2]n(2, 3D framework)两个配位聚合物。根据配位聚合物的结构特点,研究了这两个配位聚合物荧光性质等物理化学性能。配位聚合物1在最大激发波长(λex=346 nm)激发下,荧光的最大发射波长为552 nm,配位聚合物2在最大激发波长(λex=369 nm)激发下,荧光的最大发射波长为444 nm。这可能是由于金属和配体之间发生了电荷转移(LMCT)。 相似文献
58.
《Arabian Journal of Chemistry》2022,15(9):104086
In this paper, we studied commercially available precipitated rice husk silica (RHS) with conventional precipitated silica, which has nearly the same surface area, and replaced part of the carbon black with RHS and conventional silica in a basic tread formulation. All formulations were mixed with the same amount of filler during the study. Silica was used at 15, 30 and 50 phr loading, and part of the carbon black was replaced by silica. Compound curing characteristics, physical properties, rebound resilience, heat generation, abrasion loss, dynamic properties and morphology were analyzed. The results indicated that RHS demonstrated compound properties comparable to those of conventional silica. As part of the carbon black was replaced with conventional silica, a slower cure rate, higher rebound resilience, lower heat generation, lower abrasion loss, and lower tan delta were observed with no significant change in physical properties, but some changes in physical properties were observed using one way ANOVA analysis. We found the same trend when replacing part of the carbon black with RHS, such as a slower cure rate, higher rebound resilience, lower heat generation, lower abrasion loss, and lower tan delta with no significant change in physical properties, but some changes in physical properties were observed using one way ANOVA. This sustainable material could be used to replace conventional silica in tire compounding, as well as to replace a portion of carbon black with RHS for improved heat build-up, rolling resistance, and abrasion loss. 相似文献
59.
60.
In this article, capillary electrophoresis was used to measure the effective electrophoretic mobility of ester betulin derivatives as a pH function and to study their complexation with γ-cyclodextrin (γ-CD). The electrophoretic mobility of betulin 3,28-diphthalate (DPhB) and 3,28-disuccinate (DScB) changed unusually with decreasing pH: instead of decreasing, it first increased and then decreased. This fact as well as the turbidity of sample solutions at pH from 2.5 to 6, broadening of electrophoretic peaks and a decrease in the surface tension of the solutions indicates that these betulin derivatives, being amphiphilic compounds and weak acids, exist as micelles in aqueous solutions at pH 6 and below. The inclusion complexation of betulin derivatives with γ-CD at pH 9.18 and 4.5 was studied by mobility shift affinity capillary electrophoresis. At pH 9.18, the apparent binding (stability) constant logarithms for 1:1 γ-CD complexes of DPhB, betulin 3,28-disulfate (DSB) and DScB with 95% confidence interval limits were equal to 7.44 ± 0.02, 7.09 (7.01–7.19), and 6.97 (6.87–7.08) at 25°C, respectively. At pH 4.5, the binding constant for the DSB complex was slightly lower, while the micelle formation did not allow determining the exact values of the constants for the DPhB and DScB complexes. 相似文献